Interaction Between Immune and Cancer Cells and Promising CAR T-cell Therapy

CD8⁺cytotoxic T cells, CD4⁺ helper and regulatory cells interact differently with cancer. CD8⁺ cytotoxic recognize the antigens presented by cancer kill in various ways. recruit other immune promote them to destroy cells. On hand, suppress cell proliferation response of both This suppressive mechanism often leads progression These cell-cancer interactions can render conventional treatments ineffective, leaving a need for new improved therapies. Chimeric antigen receptor (CAR) T-cell therapy has been an emerging immunotherapy especially against B cancers. While CAR shown some successful cases, there are still limitations that be overcome.